刘哲教授,山东省“泰山学者海外特聘专家”,B体育官网“抗癌药物开发及诊疗应用研究所”所长,化学学科研究中心副主任,山东师范大学博士生导师,济南大学客座教授,博士后指导教师,英国皇家化学会会员,国际生物无机化学会会员,中国化学会会员。承担国家自然科学基金、省泰山学者基金等多项基金。多次受邀为ACS、RSC、Elsevier、Springer等国际出版社旗下的众多刊物审稿。
2008至2011年获WPRS奖学金,师从英国皇家科学院院士Peter J. Sadler教授,在英国华威大学获得化学专业博士学位;2012-2015年分别在英国华威大学和瑞士巴塞尔大学从事研究工作,2015年以“泰山学者海外特聘专家”加盟B体育官网,并任“抗癌药物开发及诊疗应用研究所”所长。
科研成果
主要研究领域为生物无机化学,研究方向包括:金属配合物药物化学;新型金属抗癌药物的设计、开发及作用机理研究;新型纳米材料设计、合成及肿瘤诊疗一体化研究;金属配合物在生物催化及催化聚合中的应用等。目前在金属化合物抗癌和生物催化领域均取得了一系列开拓性研究成果,打破了科学界对铱化合物药用局限的传统观念。对代表性铱化合物(ZL105)开展的抗癌和生物催化研究,已被美国Science Daily和英国BBC连续报道,在国际上产生重大影响。代表性论文包括Acc. Chem. Res.(IF = 20.833,他引120余次)1篇, Angew. Chem. Int. Ed.(IF = 13.734,一篇被评为VIP文章)4篇, J. Med. Chem.(IF = 5.614,他引120余次)1篇。海外期间作为第一完成人参与国际科研项目四项,其中重大项目两项(European Research Council, Swiss National Science Foundation,科研经费156.5万欧元和25万瑞士法郎)。
研究生招生
研究生招生方向为有机化学、无机化学等,指导的研究生获得国家奖学金、优秀研究生和圣地英才奖等多种奖励和荣誉。欢迎勤奋有毅力的优秀同学加入本组。
课题组网站:https://mbac.qfnu.edu.cn/index.htm
邮箱:liuzheqd@163.com
代表性论文
(1)Wang, C.; Liu, J.; Tian, Z.; Tian, M.; Tian, L.; Zhao, W.; Liu, Z.* Half-Sandwich Iridium N-Heterocyclic Carbene Anticancer Complexes. Dalton Trans. 2017, DOI: 10.1039/C1037DT00575J. (Impact Factor:4.177)
(2)0Du, J.; Liu, J.; Gong, P.; Tian, M.; Sun, L.; Ji, S.; Zhang, L.; Liu, Z.* Construction of a novel fluorinated graphene-based magnetic nanocomposite and its application in cancer photo-chemotherapy. Mater. Lett. 2017, 196, 165-167. (Impact Factor:2.437)
(3)Liu, Z.; Lebrun, V.; Kitanosono, T.; Mallin, H.; Köhler, V.; Häussinger, D.; Hilvert, D.; Kobayashi, S.; Ward, T. R. Upregulation of an Artificial Zymogen by Proteolysis. Angew. Chem. Int. Ed. 2016, 55, 11587–11590. (Impact Factor:11.709)
(4)Liu, Z.; Romero-Canelón, I.; Qamar, B.; Hearn, J. M.; Habtemariam, A.; Barry, N. P. E.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. The Potent Oxidant Anticancer Activity of Organoiridium Catalysts, Angew. Chem. Int. Ed. 2014,53, 3941-3946. (VIP,Impact Factor:13.734,reported by BBC and Science Daily)
(5)Liu, Z.; Sadler, P. J. Organoiridium Complexes: Anticancer Agents and Catalysts. Acc. Chem. Res. 2014, 47, 1174-1185. (Impact Factor:20.833)
(6)Liu, Z.; Deeth, R. J.; Butler, J. S.; Habtemariam, A.; Newton, M. E.; Sadler, P. J. Reduction of Quinones by NADH Catalyzed by Organoiridium Complexes. Angew. Chem., Int. Ed. 2013, 52, 4194-4197. (Impact Factor:13.734)
(7)Betanzos-Lara, S.; Liu, Z. (equal first author); Habtemariam, A.; Pizarro, A. M.; Qamar, B.; Sadler, P. J. Organometallic ruthenium and iridium transfer hydrogenation catalysts using coenzyme NADH as a cofactor. Angew. Chem., Int. Ed.2012,51, 3897-3900. (Impact Factor:13.734)
(8)Liu, Z.; Romero-Canelón, I.; Habtemariam, A.; Clarkson, G. J.; Sadler, P. J. Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C^N-Chelated and Pyridine Ligands. Organometallics 2014, 33, 5324-5333. (Impact Factor:4.145)
(9)Liu, Z.; Sadler, P. J. Formation of Glutathione Sulfenate and Sulfinate Complexes by an Organoiridium(III) Anticancer Complex. Inorg. Chem. Front. 2014, 1, 668-672. (Impact Factor:4.532)
(10)Liu, Z.; Habtemariam, A.; Pizarro, A. M.; Fletcher, S. A.; Kisova, A.; Vrana, O.; Salassa, L.; Bruijnincx, P. C. A.; Clarkson, G. J.; Brabec, V.; Sadler, P. J. Organometallic half-sandwich iridium anticancer complexes. J. Med. Chem. 2011, 54, 3011-3026. (Impact Factor:5.614)
(11)Liu, Z.; Salassa, L.; Habtemariam, A.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. Contrasting reactivity and cancer cell cytotoxicity of isoelectronic organometallic iridium(III) complexes. Inorg. Chem. 2011, 50, 5777-5783. (Impact Factor:4.593)
(12)Liu, Z.; Habtemariam, A.; Pizarro, A. M.; Clarkson, G. J.; Sadler, P. J. Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N-chelating ligands. Organometallics 2011,30, 4702-4710. (Impact Factor:4.145)
(13)Gong, P.; Wang, J.; Hou, K.; Yang, Z.; Wang, Z.; Liu, Z.; Han, X.; Yang, S. Small but strong: The influence of fluorine atoms on formation and performance of graphene quantum dots using a gradient F-sacrifice strategy. Carbon 2017, 112, 63-71.(Impact Factor:6.189)
(14)Du, J.; Liu, J.; Gong, P.; Tian, M.; Sun, L.; Ji, S.; Zhang, L.; Liu, Z.* Construction of a novel fluorinated graphene-based magnetic nanocomposite and its application in cancer photo-chemotherapy. Materials Letters. 2017
(15)Guo, L.; Jing, X.; Xiong, S.; Liu, W.; Liu, Y.; Liu, Z.; Chen, C. Influences of Alkyl and Aryl Substituents on Iminopyridine Fe(II)- and Co(II)-Catalyzed Isoprene Polymerization. Polymers 2016, 8, 389. (Impact Factor:3.043)
(16)Fu, Y.; Sanchez-Cano, C.; Soni, R.; Romero-Canelon, I.; Hearn, J. M.; Liu, Z.; Wills, M.; Sadler, P. J. The contrasting catalytic efficiency and cancer cell antiproliferative activity of stereoselective organoruthenium transfer hydrogenation catalysts. Dalton Trans.2016, 45, 8367-8378. (Impact Factor:4.177)
(17)Novohradsky, V.; Zerzankova, L.; Stepankova, J.; Kisova, A.; Kostrhunova, H.; Liu, Z.; Sadler, P. J.; Kasparkova, J.; Brabec, V. A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex. Metallomics 2014, 6, 1491-1501. (Impact Factor:4.099)
(18)Novohradsky, V.; Liu, Z.; Vojtiskova, M.; Sadler, P. J.; Brabec, V.; Kasparkova, J. Mechanism of Cellular Accumulation of an Iridium(III) Pentamethylcyclopentadienyl Anticancer Complex Containing a C,N-Chelating Ligand. Metallomics 2014, 6, 682-690. (Impact Factor:4.099)
(19)Hearn, J. M.; Romero-Canelón, I.; Qamar, B.; Liu, Z.; Hands-Portman, I.; Sadler, P. J. Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis. ACS Chem. Biol. 2013, 8, 1335-1343. (Impact Factor:5.442)
(20)Qi, Y; Liu, Z.; Li, H.; Sadler, P. J.; O’Connor, P. B. Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation. Rapid Commun. Mass Spectrom. 2013, 27, 2028-2032. (Impact Factor:2.509)